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The Frances Hollis Brain Foundation is a private family foundation whose mission is to support IRS tax-exempt organizations and projects that serve disadvantaged, underserved and/or vulnerable communities.

David and Frances Brain established the Foundation in 1993 as a tangible expression of their values. Through the Foundation, they sought with their family to address their social concerns and to encourage future generations of the family to contribute to the well-being of their communities. David named the Foundation in honor of his wife, Frances Hollis Brain, who passed away in 2012.

The Foundation focuses its efforts in Kentucky, Georgia and Maine.